Andy Smith misses out after making his Quins RL debut last Saturday at the Twickenham Stoop.
Tyrone was a leading light in Quins' senior Academy victory last weekend (22-10) against Warrington, landing a brace of tries and earning a recall in the process.
McDermott said: "Tyrone is being rewarded for a very strong performance in the lower grade and he has forced his way back into the squad."
Quins have again decided to give Richard Villasanti more time to fully complete his rehabilitation, a healthy stock of forwards enabling McDermott to do so: "We're in a comfortable position at the moment with Richard. We have all our props (Mills, Temata, McCarthy-Scarsbrook, Heckenberg) as well as Mikey (Worrincy) available, and that enables us to bring Villa back in our own time."
"When he does come in he'll be here for the long haul and be above and beyond his rehab."
Lee Hopkins (rib) and Zebastian Luisi (hand) are both still unavailable through injury.
Tony Clubb, Dave Tootill and Joe Walsh were all on hand in last week's Academy victory.
Wigan Warriors v Harlequins RL, Friday 9th March, kick-off 8pm
There are still some places available for Friday's trip on the supporters' coach. Simply call
020 8410 6000 to book.
Prices for the return coach travel are £25 adults and £18 children and concessions. The coach is fully equipped with toilet facilities and refreshments, minimizing the need for unscheduled stops.
Wigan Warriors
8pm Friday 9th March - JJB Stadium
Pick up and drop off points:
1100 Twickenham Stoop
1230 Holiday Inn Brent Cross/Staples Corner
1300 South Mimms Services/M25
The return journey will also drop off at Trafalgar Square to link with the night bus service.
Wigan Warriors 20: Ashton, Calderwood, Bailey, Withers, Richards, Barrett, Leuluai, Fielden, Higham, Paleaaesina, Hock, Fletcher, O'Loughlin, Vaealiki, Millard, Prescott, Hansen, Goulding, Hill, O'Carroll.
Harlequins RL 18: Gafa, Grayshon, Heckenberg, Hill, McLinden, McCarthy-Scarsbrook, Melling, Mills, Orr, Paul, Purdham, Randall, Rinaldi, T. Smith, Sykes, Temata, Wells, Worrincy.
Referee: I Smith
Harlequins RL v Bradford Bulls, 3pm Saturday 17th March, Twickenham Stoop
Supporters can still purchase a
2007 Quins RL Season Ticket from just £99!
Fans can also book match tickets in advance and save either
online or on the phone
020 8410 6000. Tickets start at just £12.